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ey0017.5-7 | Translational Highlights | ESPEYB17

5.7. RANKL Inhibition in fibrous dysplasia of bone: A preclinical study in a mouse model of the human disease

B Palmisano , E Spica , C Remoli , R Labella , A Di Filippo , S Donsante , F Bini , D Raimondo , F Marinozzi , A Boyde , P Robey , A Corsi , M Riminucci

To read the full abstract: J Bone Miner Res. 2019;34(12):21712182.In brief: The effect of RANKL inhibition on fibrous dysplasia development is explored here using a mouse model of a fibrous dysplasia-like disorder. Anti-mouse RANKL monoclonal antibody treatment prevented the development and growth of lesions. However, after discontinuation of anti-mouse ...

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ey0019.12-10 | Metabolic syndrome | ESPEYB19

12.10. Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

P. Sato S, Dyar KA, Treebak JT, Jepsen SL, Ehrlich AM, Ashcroft SP, Trost K, Kunzke T, Prade VM, Small L, Basse AL, Schonke M, Chen S, Samad M, Baldi P, Barres R, Walch A, Moritz T, Holst JJ, Lutter D, Zierath JR, Sassone-Corsi

Cell metabolism 2022;34(2):329-45.e8. doi: 10.1016/j.cmet.2021.12.016Brief Summary: In a mouse model, time of exercise during the day was found to determine the magnitude and type of metabolic response. Different tissues responded to exercise at different times of the day.Comment: Exercise is considered a vital intervention in the prevention and treatment of individu...

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ESPE Yearbook of Paediatric Endocrinology

5.7. RANKL Inhibition in fibrous dysplasia of bone: A preclinical study in a mouse model of the human disease

12.10. Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

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